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dc.contributor.advisor Sigdel, Krishna en
dc.contributor.author Leon Aldape, Marc en
dc.contributor.author Maayah, Yara en
dc.contributor.author Quintero, Natalie en
dc.contributor.author Patel, Urval en
dc.contributor.author Sigdel, Krishna en
dc.date.accessioned 2020-05-21T00:29:06Z en
dc.date.issued 2020-05-20 en
dc.identifier.uri http://hdl.handle.net/10211.3/215945 en
dc.description.abstract Atomic force microscopy (AFM) is a technique that can be used to probe an individual bio-molecule in physiological buffer conditions. It can resolve absolute distances down to atomic (~1Å) length scales and sub-pN force levels, which can provide real-time, dynamic pictures of macromolecules at work. For AFM measurements, the molecules under study must immobilize on a surface. While preparing these surfaces coupled assays, one should be careful to choose the right condition, in that the molecules are only gently attached to the surface to preserve their dynamics. DNA is a very important and fundamental biological macromolecule that stores the genetic information needed for cellular functions. In this study, we imaged DNA in physiological buffer condition toward probing dynamics and mechanical properties of DNA at various conditions in single molecule level. en
dc.format.extent 4 pgs. en
dc.language.iso en en
dc.publisher California State Polytechnic University, Pomona en
dc.rights.uri http://www.cpp.edu/~broncoscholar/rightsreserved.html en
dc.subject atomic force microscopy en
dc.subject biomolecule en
dc.subject physiological buffer conditions en
dc.title Single Molecule Atomic Force Microscopy Imaging of DNA for Dynamics and Mechanical Properties of DNA en
dc.type Student Research en
dc.description.embargoterms 2 years en
dc.date.embargountil 2022-05-21T00:29:06Z en
dc.contributor.department Department of Physics and Astronomy en
dc.contributor.department Department of Biological Sciences en
dc.rights.license All rights reserved en

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